Small-Molecule Patterning via Prefunctionalized Alkanethiols.

ABSTRACT: Interactions between small molecules and biomolecules are important physiologically and for biosensing, diagnostic, and therapeutic applications. To investigate these interactions, small molecules can be tethered to substrates through standard coupling chemistries. While convenient, these approaches co-opt one or more of the few small-molecule functional groups needed for biorecognition. Moreover, for multiplexing, individual probes require different surface functionalization chemistries, conditions, and/or protection/deprotection strategies. Thus, when placing multiple small-molecules on surfaces, orthogonal chemistries are needed that preserve all functional groups and are sequentially compatible. Here, we approach high-fidelity small-molecule patterning by coupling small-molecule neurot

SUBMITTER: Cao HH 

PROVIDER: S-EPMC6393937 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature