Reference markers of bone turnover for prediction of fracture: a meta-analysis.

ABSTRACT:

Objective

To explore whether bone turnover biomarkers (BTMs), i.e., C-terminal telopeptide of type I collagen (CTX) and procollagen type I aminoterminal propeptide (PINP), are associated with fracture.

Methods

We searched electronic database including PubMed, Embase and Cochrane Library, and the reference lists of relevant articles published from inception to August 22, 2018. An updated meta-analysis was performed to assess the prediction value of CTX and PINP in fracture.

Results

Nine articles met our inclusion criteria and were included in the meta-analysis. The crude and adjusted effect size between PINP and fracture were extracted from two and five studies, respectively. PINP was not associated with fracture incidence without adjusting covariates (crude GR, 1.03;

SUBMITTER: Tian A 

PROVIDER: S-EPMC6393999 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature