IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common cancers worldwide, and genetic variations exert distinct roles in its pathogenesis. Single nucleotide polymorphisms (SNPs) in interleukin 1 alpha (IL1A) were reported to be correlated to the susceptibility of diverse cancers. The aim of this study was to assess the association of IL1A SNPs with the risk of colorectal cancer in a Chinese Han population.

Methods

To evaluate the correlation between IL1A polymorphisms and CRC risk, Agena MassARRAY platform was used for genotype determination among 248 CRC patients and 463 controls. The relationships between IL1A variants and CRC susceptibility were examined by logistic regression analysis. Stratified analysis was conducted for the association detection in males and fem

SUBMITTER: Ji H 

PROVIDER: S-EPMC6394039 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature