Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway.

ABSTRACT:

Background

The morbidity of nephrolithiasis is 2-3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important pathophysiological process contributing to the development of nephrolithiasis. Therefore, the aim of this study is to investigate whether androgen directly induces TECs apoptosis and necrosis and its underlying mechanisms in kidney stone formation.

Materials and methods

We compared serum testosterone level between male and female healthy volunteers and kidney stone patients. The in vivo nephrolithiasis model was established using glyoxylic acid, and calcium deposits were detected by van Kossa staining. In the in vitro study using mouse TECs (TCMK-1 cells) and

SUBMITTER: Peng Y 

PROVIDER: S-EPMC6394048 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature