Animal models with group-specific additive genetic variances: extending genetic group models.

ABSTRACT:

Background

The animal model is a key tool in quantitative genetics and has been used extensively to estimate fundamental parameters, such as additive genetic variance or heritability. An implicit assumption of animal models is that all founder individuals derive from a single population. This assumption is commonly violated, for instance in crossbred livestock or when a meta-population is split into genetically differentiated subpopulations. Ignoring that base populations are genetically heterogeneous and thus split into different 'genetic groups' may lead to biased parameter estimates, especially for additive genetic variance. To avoid such biases, genetic group animal models, which account for the presence of more than one genetic group, have been proposed. Unfortunately, the met

SUBMITTER: Muff S 

PROVIDER: S-EPMC6394059 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature