Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of <i>Streptococcus pyogenes in vitro</i> and <i>in vivo</i>.

ABSTRACT: Streptococcus pyogenes is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial nucleic acids, especially bacterial RNA, have recently been recognized as a major group of pathogen-associated molecular patterns (PAMPs) involved in the detection of Streptococcus pyogenes via endosomal Toll-like receptors (TLRs) in vitro. However, the individual contribution and cooperation between TLRs as well as cell-type and strain specific differences in dependency on nucleic acid detection during S. pyogenes infection in vitro have not been clarified in detail. Moreover, the role of particularly bacterial RNA for the defense of S. pyogenes infection in vivo rema

SUBMITTER: Hafner A 

PROVIDER: S-EPMC6394247 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature