Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet.

ABSTRACT: Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. In the present study, the possibility of using a permanent magnet for trapping the particles on a lung tumor is evaluated numerically in the Weibel's model from G0 to G3. The effect of different parameters is considered on the efficiency of particle deposition in a tumor located on a distant position of the lung bronchi and bronchioles. Also, the effective position of the magnetic source, tumor size, and location are the objecti

SUBMITTER: Manshadi MKD 

PROVIDER: S-EPMC6394297 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature