Aberrantly hydroxymethylated differentially expressed genes and the associated protein pathways in osteoarthritis.

ABSTRACT:

Background

The elderly population is at risk of osteoarthritis (OA), a common, multifactorial, degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA hydroxymethylation) factors may be involved in the etiology, development, and pathogenesis of OA. Here, comprehensive bioinformatic analyses were used to identify aberrantly hydroxymethylated differentially expressed genes and pathways in osteoarthritis to determine the underlying molecular mechanisms of osteoarthritis and susceptibility-related genes for osteoarthritis inheritance.

Methods

Gene expression microarray data, mRNA expression profile data, and a whole genome 5hmC dataset were obtained from the Gene Expression Omnibus repository. Differentially expressed genes with abnormal hydroxymethylatio

SUBMITTER: Fang Y 

PROVIDER: S-EPMC6394344 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature