Volumetric and texture analysis of pretherapeutic ¹⁸F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib.

ABSTRACT:

Purpose

The metabolically most active lesion in 2-deoxy-2-(¹⁸F)fluoro-D-glucose (¹⁸F-FDG) PET/CT can predict progression-free survival (PFS) in patients with medullary thyroid carcinoma (MTC) starting treatment with the tyrosine kinase inhibitor (TKI) vandetanib. However, this metric failed in overall survival (OS) prediction. In the present proof of concept study, we aimed to explore the prognostic value of intratumoral textural features (TF) as well as volumetric parameters (total lesion glycolysis, TLG) derived by pre-therapeutic ¹⁸F-FDG PET.

Methods

Eighteen patients with progressive MTC underwent baseline ¹⁸F-FDG PET/CT prior to and 3 months after vandetanib initiation. By manual segmentation of the tumor burden at baseline an

SUBMITTER: Werner RA 

PROVIDER: S-EPMC6394453 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature