The association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study.

ABSTRACT: Background Polypharmacy is a growing health concern for older adults and is associated with poorer clinical outcome. Objective This study aim is to investigate the association between polypharmacy and impairment in cognitive, physical and emotional capability controlling for the confounding effect of co-morbidities. Setting The Aberdeen 1936 Birth Cohort from 1999 to 2004. Method Recruited were 498 dementia free participants around 64 years old and recruited into wave one. Linear regression and structural equation models were used. Models were adjusted for the effect of age, gender, childhood IQ, education and Body Mass Index. A triad of impairment was defined as a composite measure of impairment in cognitive, physical and emotional function. Main outcome measure The relationships between

SUBMITTER: Khezrian M 

PROVIDER: S-EPMC6394523 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature