The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review.

ABSTRACT:

Purpose

There is a strong need to improve the prognostication of breast cancer patients in order to prevent over- and undertreatment, especially when considering adjuvant chemotherapy. Tumour stroma characteristics might be valuable in predicting disease progression.

Methods

Studies regarding the prognostic value of tumour-stroma ratio (TSR) in breast cancer are evaluated.

Results

A high stromal content is related to a relatively poor prognosis. The most pronounced prognostic effect of this parameter seems to be observed in the triple-negative breast cancer (TNBC) subtype.

Conclusions

TSR assessment might represent a simple, fast and reproducible prognostic factor at no extra costs, and could possibly be incorporated into routine pathological diagnostics. Despi

SUBMITTER: Kramer CJH 

PROVIDER: S-EPMC6394568 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature