Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background

Circular RNAs (circRNAs), a special class of noncoding RNAs with the characteristic of covalent closed-loop structure, have been widely found in various organisms. Growing evidence has shown that circRNAs play a crucial role in regulating biological functions of cancers. However, the specific role of circRNAs in esophageal squamous cell carcinoma (ESCC) remains largely unknown.

Aim

The present study aims to investigate the effects of circ-TTC17 in ESCC clinical samples as well as cells.

Methods

Sanger sequencing and agarose gel electrophoresis were used to verify the specificity of circ-TTC17. Expression levels of circ-TTC17 in ESCC cells, plasma, and tissues were measured by quantitative real-time polymerase chain reaction. A colony formation experiment, C

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6394574 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature