Circulating Exosomal miRNA Profile During Term and Preterm Birth Pregnancies: A Longitudinal Study.

ABSTRACT: Despite decades of research in the field of human reproduction, the mechanisms responsible for human parturition still remain elusive. The objective of this study was to describe the changes in the exosomal miRNA concentrations circulating in the maternal plasma between mothers delivering term and preterm neonates, across gestation using a longitudinal study design. This descriptive study identifies the miRNA content in exosomes present in maternal plasma of term and preterm birth (PTB) (n = 20 and n = 10 per each gestational period, respectively) across gestation (i.e., first, second, and third trimesters and at the time of delivery). Changes in exosomal miRNA signature in maternal plasma during term and preterm gestation were determined using the NextSeq 500 high-output 75 cycles sequenc

SUBMITTER: Menon R 

PROVIDER: S-EPMC6394761 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature