PyPNS: Multiscale Simulation of a Peripheral Nerve in Python.

ABSTRACT: Bioelectronic Medicines that modulate the activity patterns on peripheral nerves have promise as a new way of treating diverse medical conditions from epilepsy to rheumatism. Progress in the field builds upon time consuming and expensive experiments in living organisms. To reduce experimentation load and allow for a faster, more detailed analysis of peripheral nerve stimulation and recording, computational models incorporating experimental insights will be of great help. We present a peripheral nerve simulator that combines biophysical axon models and numerically solved and idealised extracellular space models in one environment. We modelled the extracellular space as a three-dimensional resistive continuum governed by the electro-quasistatic approximation of the Maxwell equations. Potenti

SUBMITTER: Lubba CH 

PROVIDER: S-EPMC6394768 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature