Poor Antigen Processing of Poxvirus Particles Limits CD4⁺ T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine.

ABSTRACT: CD4⁺ T cells play critical roles in defending against poxviruses, both by potentiating cellular and humoral responses and by directly killing infected cells. Despite this central role, the basis for pox-specific CD4⁺ T cell activation, specifically the origin of the poxvirus-derived peptides (epitopes) that activate CD4⁺ T cells, remains poorly understood. In addition, because the current licensed poxvirus vaccines can cause serious adverse events and even death, elucidating the requirements for MHC class II (MHC-II) processing and presentation of poxviral Ags could be of great use. To address these questions, we explored the CD4⁺ T cell immunogenicity of ectromelia, the causative agent of mousepox. Having identified a large panel of novel epitop

SUBMITTER: Forsyth KS 

PROVIDER: S-EPMC6394857 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature