Genetic expression signatures of oral submucous fibrosis and oral cancer-A preliminary microarray report.

ABSTRACT:

Background/purpose

Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral squamous cell carcinoma (SCC). In this study, we obtained the genetic expression signatures of OSF and SCC by microarray analysis.

Materials and methods

Five patients with clinically evident OSF, five patients with SCC who also had existing OSF, and four normal volunteers who did not have a history of chewing betel quids were recruited. Biopsy specimens were obtained with an approved Institutional Review Board protocol. Total RNA from OSF or SCC was isolated and hybridized to a Human Oligo 1A (V2) Microarray (G4110B) chip against normal control RNA that was pooled from the four healthy volunteers.

Results

We found similar, but distinct genetic expression signatures for OSF and

SUBMITTER: Liao PH 

PROVIDER: S-EPMC6395281 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature