Association between ADIPOQ gene variants and knee osteoarthritis in a Chinese population.

ABSTRACT: A study from Thailand showed no significant association between the adiponectin (ADIPOQ) gene rs1501299 polymorphism and knee osteoarthritis (OA) risk. To investigate this association in a Chinese population, we conducted this case-control study involving 372 knee OA patients and 453 controls. Genotyping via standard PCR and restriction fragment length polymorphism (PCR-RFLP) showed that TT genotype (TT vs. GG: adjusted odds ratio (OR) (95% confidence interval (CI)) = 1.70 (1.01-2.86)) or T allele (T vs. G: adjusted OR (95% CI) = 1.26 (1.02-1.56)) of ADIPOQ gene rs1501299 polymorphism significantly increased the risk of knee OA. Significant associations were also observed in subgroups ≥55 years (TT vs. GG: adjusted OR (95% CI) = 2.21 (1.00-4.86)) and body mass index (BMI) < 25 kg/m2 (TT+GT

SUBMITTER: Shang H 

PROVIDER: S-EPMC6395300 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature