Histological characteristics of Acute Tubular Injury during Delayed Graft Function predict renal function after renal transplantation.

ABSTRACT: Acute Tubular Injury (ATI) is the leading cause of Delayed Graft Function (DGF) after renal transplantation (RTX). Biopsies taken 1 week after RTX often show extensive tubular damage, which in most cases resolves due to the high regenerative capacity of the kidney. Not much is known about the relation between histological parameters of renal damage and regeneration immediately after RTX and renal outcome in patients with DGF. We retrospectively evaluated 94 patients with DGF due to ATI only. Biopsies were scored for morphological characteristics of renal damage (edema, casts, vacuolization, and dilatation) by three independent blinded observers. The regenerative potential was quantified by tubular cells expressing markers of proliferation (Ki67) and dedifferentiation (CD133). Parameters we

SUBMITTER: Pieters TT 

PROVIDER: S-EPMC6395310 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature