Cognate Interaction With CD4⁺ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype.

ABSTRACT: The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells. Tumor associated macrophages (TAMs) showing functional plasticity contribute to this process as so called M2-like macrophages can suppress the function of effector T cells and promote their differentiation into regulatory T cells (Tregs). Furthermore, tumor antigen specific CD4⁺ T effector cells can essentially sustain anti-tumoral immune responses as shown for various tumor entities, thus suggesting that cognate interaction between tumor antigen-specific CD4⁺ Th1 cells and TAMs might shift the intra-tumoral M1/M2 ratio toward M1. This study demonstrates repolarization of M2-like PECs upon MHC II-r

SUBMITTER: Eisel D 

PROVIDER: S-EPMC6395406 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature