Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension.

ABSTRACT:

Rationale

Increased microglial activation and neuroinflammation within autonomic brain regions have been implicated in sustained hypertension, and their inhibition by minocycline-an anti-inflammatory antibiotic-produces beneficial effects. These observations led us to propose a dysfunctional brain-gut communication hypothesis for hypertension. However, it has been difficult to reconcile whether an anti-inflammatory or antimicrobial action is the primary beneficial effect of minocycline in hypertension. Accordingly, we utilized chemically modified tetracycline-3 (CMT-3)-a derivative of tetracycline that has potent anti-inflammatory activity-to address this question.

Objective

Test the hypothesis that central administration of CMT-3 would inhibit microglial activation, attenua

SUBMITTER: Sharma RK 

PROVIDER: S-EPMC6395495 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature