Protein Phosphatase 2A Regulates Cardiac Na⁺ Channels.

ABSTRACT:

Rationale

Voltage-gated Na⁺ channel ( I_Na) function is critical for normal cardiac excitability. However, the Na⁺ channel late component ( I_Na,L) is directly associated with potentially fatal forms of congenital and acquired human arrhythmia. CaMKII (Ca²⁺/calmodulin-dependent kinase II) enhances I_Na,L in response to increased adrenergic tone. However, the pathways that negatively regulate the CaMKII/Na_v1.5 axis are unknown and essential for the design of new therapies to regulate the pathogenic I_Na,L.

Objective

To define phosphatase pathways that regulate I_Na,L in vivo.

Methods and results

A mouse model lacking a key regulatory subunit (B56α) of the PP (protein phosphata

SUBMITTER: El Refaey M 

PROVIDER: S-EPMC6395500 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature