Small Numbers of CD4+ T Cells Can Induce Development of Lymphedema.

ABSTRACT:

Background

CD4 T cells have been implicated in the pathology of lymphedema. Interestingly, however, there have been case reports of lymphedema development in patients with low levels of CD4 T cells because of immunosuppression. In this study, the authors sought to delineate the effect of relative CD4 T-cell deficiency on the development of lymphedema in a mouse model.

Methods

A mouse model of relative CD4 T-cell deficiency was created through lethal total body irradiation of wild-type mice that then underwent bone marrow transplantation with progenitors harvested from CD4 knockout mice (wild-type/CD4 knockout). Irradiated CD4 knockout mice reconstituted with wild-type mouse-derived progenitors (CD4 knockout/wild-type), and unirradiated CD4 knockout and wild-type mice were us

SUBMITTER: Ly CL 

PROVIDER: S-EPMC6395505 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature