Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction.

ABSTRACT: Activity-dependent changes in the effective connection strength of synapses are a fundamental feature of a nervous system. This so-called synaptic plasticity is thought to underlie storage of information in memory and has been hypothesized to be crucial for the effects of cognitive behavioral therapy. Synaptic plasticity stores information in a neural network, creating a trace of neural activity from past experience. The plasticity can also change the behavior of the network so the network can differentially transform/compute information in future activations. We discuss these two related but separable functions of synaptic plasticity; one we call "item memory" as it represents and stores items of information in memory, the other we call "process memory" as it encodes and stores functions

SUBMITTER: O'Reilly KC 

PROVIDER: S-EPMC6395534 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature