Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism.

ABSTRACT:

Objective

In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine whether opioid receptor antagonism prior to administration of intravenous ketamine attenuates its acute antidepressant or dissociative effects.

Method

In a proposed double-blind crossover study of 30 adults with treatment-resistant depression, the authors performed a planned interim analysis after studying 14 participants, 12 of whom completed both conditions in randomized order: placebo or 50 mg of naltrexone preceding intravenous infusion of 0.5 mg/kg of ketamine. Response was defined as a reduction ≥50% in score on the 17-item Hamilton Depression Rating Scale (HAM-D) score on postinfusion day 1.

Results

In the i

SUBMITTER: Williams NR 

PROVIDER: S-EPMC6395554 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature