Benefits of Methylphenidate for Long-Term Attention Problems After Traumatic Brain Injury in Childhood: A Randomized, Double-Masked, Placebo-Controlled, Dose-Titration, Crossover Trial.

ABSTRACT:

Objective

To characterize the benefits and optimal dose of long-acting methylphenidate for management of long-term attention problems after childhood traumatic brain injury (TBI).

Design

Phase 2, randomized, double-masked, placebo-controlled, dose-titration, crossover clinical trial.

Setting

Outpatient, clinical research.

Participants

Twenty-six children aged 6 to 17 years who were at least 6 months post-TBI and met criteria for attention-deficit hyperactivity disorder (ADHD) at the time of enrollment.

Outcome measures

Vanderbilt Rating Scale of attention problems, Pittsburgh Side Effects Rating Scale, and vital signs.

Results

Among the 26 participants randomized, 20 completed the trial. The mean ages at injury and enrollment were 6.3 and 11.5 yea

SUBMITTER: Kurowski BG 

PROVIDER: S-EPMC6395577 | biostudies-literature | 2019 Mar/Apr

REPOSITORIES: biostudies-literature