Gentisic acid prevents the transition from pressure overload-induced cardiac hypertrophy to heart failure.

ABSTRACT: We previously reported that gentisic acid attenuates cardiac hypertrophy and fibrosis in transverse aortic constriction (TAC)-induced cardiac hypertrophy. Here, we examined whether gentisic acid prevents the development of heart failure. Heart failure was induced in mice via chronic TAC. Mice were administered the vehicle, gentisic acid (10 and 100 mg∙kg^-1∙day^-1), or bisoprolol (0.5 mg∙kg^-1∙day^-1) orally for 3 weeks, beginning 3 weeks after TAC. After oral administration of gentisic acid (2000 mg∙kg^-1), no significant differences in organ weight, histology, or analyzed serum and hematological parameters were observed between female mice in the control and gentisic acid-treated groups. Gentisic acid administration inhibited cardiac dysf

SUBMITTER: Sun S 

PROVIDER: S-EPMC6395621 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature