Metabolic therapies inhibit tumor growth in vivo and in silico.

ABSTRACT: In the recent years, cancer research succeeded with sensitive detection methods, targeted drug delivery systems, and the identification of a large set of genes differently expressed. However, although most therapies are still based on antimitotic agents, which are causing wide secondary effects, there is an increasing interest for metabolic therapies that can minimize side effects. In the early 20^th century, Otto Warburg revealed that cancer cells rely on the cytoplasmic fermentation of glucose to lactic acid for energy synthesis (called "Warburg effect"). Our investigations aim to reverse this effect in reprogramming cancer cells' metabolism. In this work, we present a metabolic therapy specifically targeting the activity of specific enzymes of central carbon metabolism, combin

SUBMITTER: da Veiga Moreira J 

PROVIDER: S-EPMC6395653 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature