Spatial contribution of hippocampal BOLD activation in high-resolution fMRI.

ABSTRACT: While the vascular origin of the BOLD-fMRI signal is established, the exact neurovascular coupling events contributing to this signal are still incompletely understood. Furthermore, the hippocampal spatial properties of the BOLD activation are not elucidated, although electrophysiology approaches have already revealed the precise spatial patterns of neural activity. High magnetic field fMRI offers improved contrast and allows for a better correlation with the underlying neuronal activity because of the increased contribution to the BOLD signal of small blood vessels. Here, we take advantage of these two benefits to investigate the spatial characteristics of the hippocampal activation in a rat model before and after changing the hippocampal plasticity by long-term potentiation (LTP). We fou

SUBMITTER: Abe Y 

PROVIDER: S-EPMC6395694 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature