Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction.

ABSTRACT: Maternal age has a negative effect on offspring lifespan in a range of taxa and is hypothesized to influence the evolution of aging. However, the mechanisms of maternal age effects are unknown, and it remains unclear if maternal age alters offspring response to therapeutic interventions to aging. Here, we evaluate maternal age effects on offspring lifespan, reproduction, and the response to caloric restriction, and investigate maternal investment as a source of maternal age effects using the rotifer, Brachionus manjavacas, an aquatic invertebrate. We found that offspring lifespan and fecundity decline with increasing maternal age. Caloric restriction increases lifespan in all offspring, but the magnitude of lifespan extension is greater in the offspring from older mothers. The trade-off be

SUBMITTER: Bock MJ 

PROVIDER: S-EPMC6395700 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature