Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.

ABSTRACT: The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase longevity. However, fundamental questions remain unanswered, including the temporal requirements for β5 overexpression and whether β5 overexpression can extend lifespan in other species. To determine if adult-only overexpression of the β5 subunit can increase proteasome activity in a different model, we characterized phenotypes associated with β5 overexpression in Drosophila melanogaster adults. We find that adult-only overexpression of the β5 subunit does not result in transcriptional upregulation

SUBMITTER: Nguyen NN 

PROVIDER: S-EPMC6395709 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature