Hidden in plain sight: what remains to be discovered in the eukaryotic proteome?

ABSTRACT: The first decade of genome sequencing stimulated an explosion in the characterization of unknown proteins. More recently, the pace of functional discovery has slowed, leaving around 20% of the proteins even in well-studied model organisms without informative descriptions of their biological roles. Remarkably, many uncharacterized proteins are conserved from yeasts to human, suggesting that they contribute to fundamental biological processes (BP). To fully understand biological systems in health and disease, we need to account for every part of the system. Unstudied proteins thus represent a collective blind spot that limits the progress of both basic and applied biosciences. We use a simple yet powerful metric based on Gene Ontology BP terms to define characterized and uncharacterized prot

SUBMITTER: Wood V 

PROVIDER: S-EPMC6395881 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature