Transmissible vaccines in heterogeneous populations: Implications for vaccine design.

ABSTRACT: Transmissible vaccines may provide a promising solution for improving the control of infectious disease, particularly zoonotic pathogens with wildlife reservoirs. Although it is well known that heterogeneity in pathogen transmission impacts the spread of infectious disease, the effects of heterogeneity on vaccine transmission are largely unknown. Here we develop and analyze a mathematical model that quantifies the potential benefits of a transmissible vaccine in a population where transmission is heterogeneous between two subgroups. Our results demonstrate that the effect of heterogeneity on the benefit of vaccine transmission largely depends on the vaccine design and the pattern of vaccine administration across subgroups. Specifically, our results show that in most cases a transmissible v

SUBMITTER: Varrelman TJ 

PROVIDER: S-EPMC6395884 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature