Treatment of T3N0 non-small cell lung cancer with chest wall invasion using stereotactic body radiotherapy.

ABSTRACT:

Objectives

Chest wall invasion (CWI) is observed in 5% of localized non-small cell lung cancer (NSCLC). The role of stereotactic body radiotherapy (SBRT) in these patients is unknown. We investigate the safety and efficacy of SBRT in patients with T3N0 NSCLC due to CWI.

Methods

Patients with T3N0 NSCLC due to CWI were identified using a prospective registry. CWI was defined as radiographic evidence of soft tissue invasion or bony destruction. We excluded patients with recurrent or metastatic disease. All patients were treated with definitive SBRT. Prescribed dose was 50 Gy in 5 fractions for most patients. Kaplan-Meier analysis was used to estimate survival outcomes.

Results

We identified 12 patients treated between 2006 and 2017. Median age was 70 (range, 58-85). Med

SUBMITTER: Kennedy WR 

PROVIDER: S-EPMC6396077 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature