Solution Structure of a MYC Promoter G-Quadruplex with 1:6:1 Loop Length.

ABSTRACT: The important MYC oncogene is deregulated in many cancer cells and comprises one of the most prominent G-quadruplex (G4) forming sequences in its promoter regions, the NHE III₁ motif. Formation of G4s suppresses MYC transcription and can be modulated by drug binding, establishing these DNA structures as promising targets in cancer therapy. The NHE III₁ motif can fold into more than one parallel G4s, including 1:2:1 and 1:6:1 loop length conformers, with the 1:2:1 conformer shown as the major species under physiological conditions in solution. However, additional factors such as protein interactions may affect the cellular folding equilibrium. Nucleolin, a protein shown to bind MYC G4 and repress MYC transcription, is reported herein to pref

SUBMITTER: Dickerhoff J 

PROVIDER: S-EPMC6396123 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature