CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1^- mantle cell lymphoma.

ABSTRACT: Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1. However, a small subset of cyclin D1^- MCL has been recognized, and approximately one-half of them harbor CCND2 translocations while the primary event in cyclin D1^-/D2^- MCL remains elusive. To identify other potential mechanisms driving MCL pathogenesis, we investigated 56 cyclin D1^-/SOX11⁺ MCL by fluorescence in situ hybridization (FISH), whole-genome/exome sequencing, and gene-expression and copy-number arrays. FISH with break-apart probes identified CCND2 rearrangements in 39 cases (70%) but not CCND3 rearrangements. We analyzed 3 of these negative cases by whole-genome/exome sequencing and

SUBMITTER: Martin-Garcia D 

PROVIDER: S-EPMC6396173 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature