A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

ABSTRACT: Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a trans-ancestry meta-analysis. Our primary analysis included the 7 studies that measured FVII activity, and a secondary analysis included all 9 studies. We provided functional genomic validation for newly identified significant loci by silencing candidate genes in a human liver cell l

SUBMITTER: de Vries PS 

PROVIDER: S-EPMC6396174 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature