Sex differences in HIV-associated cognitive impairment.

ABSTRACT:

Objective

We determined whether there are sex differences in the prevalence and profile of HIV-associated neurocognitive impairment, and whether sex moderates the effect of HIV-serostatus on neurocognitive impairment among HIV-positive and HIV-negative individuals. Secondarily, we assessed whether differences were explained by greater biopsychosocial risk factors in HIV-positive women.

Design

An observational cohort study.

Methods

Analyses included 1361 HIV-positive (204 women) and 702 HIV-negative (214 women) (ages = 18-79 years) participants from the UCSD HIV Neurobehavioral Research Program. Demographically corrected standardized T-scores from 15 neuropsychological tests were used to calculate domain-specific and global deficit scores (GDS). GDS at least 0.5 define

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC6396274 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature