The Free Energy Landscape of Internucleosome Interactions and Its Relation to Chromatin Fiber Structure.

ABSTRACT: The supramolecular chromatin fiber is governed by molecular scale energetics and interactions. Such energetics originate from the fiber's building block, the nucleosome core particle (NCP). In recent years, the chromatin fiber has been examined through perturbative methods in attempts to extract the energetics of nucleosome association in the fiber. This body of work has led to different results from experiments and simulations concerning the nucleosome-nucleosome energetics. Here, we expand on previous experiments and use coarse-grained simulations to evaluate the energetics inherent to nucleosomes across a variety of parameters in configurational and environmental space. Through this effort, we are able to uncover molecular processes that are critical to understanding the 30 nm chromatin

SUBMITTER: Moller J 

PROVIDER: S-EPMC6396382 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature