Signature MicroRNA expression profile is associated with lipid metabolism in African green monkey.

ABSTRACT:

Background

Non-human primates (NHPs) are important models of medical research on obesity and cardiovascular diseases. As two of the most commonly used NHPs, cynomolgus macaque (CM) and African green monkey (AGM) own different capacities in lipid metabolism of which the mechanism is unknown. This study investigated the expression profiles of lipid metabolism-related microRNAs (miRNAs) in CM and AGM and their possible roles in controlling lipid metabolism-related gene expression.

Methods

By small RNA deep sequencing, the plasma miRNA expression patterns of CM and AGM were compared. The lipid metabolism-related miRNAs were validated through quantitative reverse-transcription (RT) polymerase chain reaction (PCR). Related-target genes were predicted by TargetScan and validated in

SUBMITTER: Zhou XJ 

PROVIDER: S-EPMC6396449 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature