Statistical design and analysis in trials of proportionate interventions: a systematic review.

ABSTRACT:

Background

In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluation of the effectiveness of the individual stages in addition to the whole intervention. However, evaluating individual stages of an intervention has various challenges, particularly the statistical design and analysis. This review aimed to identify the use of trials of proportionate interventions and how they are being designed and analysed in current practice.

Methods

We searched MEDLINE, Web of Science and PsycINFO for articles published between 2010 and 2015 inclusive. We considered trials of proportionate interventions in all

SUBMITTER: Candlish J 

PROVIDER: S-EPMC6396459 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature