An update on glucose-6-phosphate dehydrogenase deficiency in children from Brazzaville, Republic of Congo.

ABSTRACT:

Background

Malaria transmission-blocking anti-malarial drugs, such as primaquine, offers an effective strategy for reducing the incidence of falciparum malaria. However, this drug induces haemolytic anaemia among glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. The distribution of G6PD deficiency in Brazzaville, Republic of Congo and the association of G6PD deficiency with haemoglobin levels and blood cell counts were investigated.

Methods

A total of 212 febrile children were recruited for this study. Plasmodium falciparum diagnosis was conducted by microscopy and nested PCR. Sanger sequencing was used to assess G6PD deficiency by detecting 202G>A (rs1050828) and 376A>G (rs1050829) single nucleotide polymorphisms.

Results

Two hundred and twelve children

SUBMITTER: Gampio Gueye NS 

PROVIDER: S-EPMC6396490 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature