Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

ABSTRACT:

Background

Prenatal exposure to arsenic has been linked to a range of adverse health conditions in later life. Such fetal origins of disease are frequently the result of environmental effects on the epigenome, leading to long-term alterations in gene expression. Several studies have demonstrated effects of prenatal arsenic exposure on DNA methylation; however the impact of arsenic on the generation and decoding of post-translational histone modifications (PTHMs) is less well characterized, and has not been studied in the context of prenatal human exposures.

Methods

In the current study, we examined the effect of exposure to low-to-moderate levels of arsenic in a US birth cohort, on the expression of 138 genes encoding key epigenetic regulators in the fetal portion of the pla

SUBMITTER: Winterbottom EF 

PROVIDER: S-EPMC6396530 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature