Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values.

ABSTRACT:

Background

We developed a method to calculate a standard score for lung tissue mass derived from CT scan images from a control group without respiratory disease. We applied the method to images from subjects with emphysema associated with alpha-1 antitrypsin deficiency (AATD) and used it to study regional patterns of differential tissue mass.

Methods

We explored different covariates in 76 controls. Standardization was applied to facilitate comparability between different CT scanners and a standard Z-score (Standard Mass Score, SMS) was developed, representing lung tissue loss compared to normal lung mass. This normative data was defined for the entire lungs and for delineated apical, central and basal regions. The agreement with D_LCO%pred was explored in a data se

SUBMITTER: Stoel BC 

PROVIDER: S-EPMC6396535 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature