Extensively drug-resistant Gram-negative bacterial bloodstream infection in hematological disease.

ABSTRACT:

Background

Extensively drug-resistant Gram-negative bacterial (XDR-GNB) bloodstream infection (BSI) is difficult to treat and is associated with a high mortality rate in patients with hematological diseases. The aim of this study is to investigate the predisposing risk factors and the efficacy of the antibiotic treatment in these patients, including exploration of efficacy and adverse effects of high-dose tigecycline.

Methods

Between January 2013 and December 2017, 27 XDR-GNB BSI patients with hematological diseases were diagnosed and retrospectively reviewed in the current study.

Results

Clinical response in patients with severe complications (such as severe neutropenia >10 days, grade III-IV acute graft-versus-host disease (aGVHD), and concurrent pneumonia) was sign

SUBMITTER: Zhou L 

PROVIDER: S-EPMC6396657 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature