Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas.

ABSTRACT:

Background

The dominant invasive breast cancer histologic subtype, ductal carcinoma, shows intrinsic subtype diversity. However, lobular breast cancers are predominantly Luminal A. Both histologic subtypes show distinct relationships with patient and tumor characteristics, but it is unclear if these associations remain after accounting for intrinsic subtype.

Methods

Generalized linear models were used to estimate relative frequency differences (RFDs) and 95% confidence intervals (95% CIs) for the associations between age, race, tumor characteristics, immunohistochemistry (IHC) and RNA-based intrinsic subtype, TP53 status, and histologic subtype in the Carolina Breast Cancer Study (CBCS, n = 3,182) and The Cancer Genome Atlas (TCGA, n = 808).

Results

Relative to ductal

SUBMITTER: Williams LA 

PROVIDER: S-EPMC6396692 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature