Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.

ABSTRACT:

Importance

The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode.

Objective

To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin).

Design, setting, and patients

This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of the Psychiatric Genomics Consortium. Data sets were drawn from case-control, cohort, and population-based studies, including 26 628 partic

SUBMITTER: Milaneschi Y 

PROVIDER: S-EPMC6396812 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature