Modelling the dose-response relationship: the fair share of pharmacokinetic and pharmacodynamic information.

ABSTRACT:

Aims

The aim of this paper is to investigate the role of drug concentration samplings in the modelling of the dose-response relationship.

Methods

Using an initial PK/PD model, a reference dataset was simulated. PK and PD samples were extracted to create reduced datasets. PK/PD and K-PD models were fitted to theses reduced datasets. Post hoc estimates from both types of models were compared to the initial PK/PD model and performance was assessed.

Results

K-PD models were largely biased when the drug has a nonlinear elimination. PK/PD models with 1 PK and 2 PD samples were superior to K-PD models with 3 PD samples. PK/PD models with 1 or 2 PK samples and 3 PD samples proved to be superior to K-PD models with 4 PD samples.

Conclusions

K-PD models should not be use

SUBMITTER: Gonzalez-Sales M 

PROVIDER: S-EPMC6396849 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature