Incident thyroid disease in female spouses of private pesticide applicators.

ABSTRACT:

Background

Little is known about modifiable risk factors for thyroid disease. Several pesticides have been implicated in thyroid disruption, but clinical implications are not clear.

Objective

We assessed associations between pesticide use and other farm exposures and incident hypothyroidism and hyperthyroidism in female spouses of farmers in the Agricultural Health Study (AHS).

Methods

We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals for risk of thyroid disease in 24,092 spouses who completed at least one follow-up questionnaire.

Results

We identified 1627 hypothyroid and 531 hyperthyroid cases over 20 years of follow-up. The fungicides benomyl, maneb/mancozeb, and metalaxyl, the herbicide pendimethalin, and am

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC6396853 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature