BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Rationale

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable course.

Objectives

To determine whether BAL cell gene expression is predictive of survival in IPF.

Methods

This retrospective study analyzed the BAL transcriptome of three independent IPF cohorts: Freiburg (Germany), Siena (Italy), and Leuven (Belgium) including 212 patients. BAL cells from 20 healthy volunteers, 26 patients with sarcoidosis stage III and IV, and 29 patients with chronic obstructive pulmonary disease were used as control subjects. Survival analysis was performed by Cox models and component-wise boosting. Presence of airway basal cells was tested by immunohistochemistry and flow cytometry.

Measurements and main results

A total of 1,582 genes were p

SUBMITTER: Prasse A 

PROVIDER: S-EPMC6396865 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature