Impedance-Based Microfluidic Assay for Automated Antischistosomal Drug Screening.

ABSTRACT: Schistosomiasis is a neglected tropical disease, caused by parasitic worms, which affects almost 200 million people worldwide. For over 40 years, chemotherapeutic treatment has relied on the administration of praziquantel, an efficacious drug against schistosomiasis. However, concerns about developing drug resistance require the discovery of novel drug compounds. Currently, the drug-screening process is mostly based on the visual evaluation of drug effects on worm larvae in vitro by a trained operator. This manual process is extremely labor-intensive, has limited throughput, and may be affected by subjectivity of the operator evaluation. In this paper, we introduce a microfluidic platform with integrated electrodes for the automated detection of worm larvae viability using an impedance-bas

SUBMITTER: Chawla K 

PROVIDER: S-EPMC6396876 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature